Interleukin-1 beta-mediated regulation of mu-opioid receptor mRNA in primary astrocyte-enriched cultures.

@article{Ruzicka1996Interleukin1BR,
  title={Interleukin-1 beta-mediated regulation of mu-opioid receptor mRNA in primary astrocyte-enriched cultures.},
  author={Bianca B. Ruzicka and Robert A. Thompson and Stanley J. Watson and Huda Akil},
  journal={Journal of neurochemistry},
  year={1996},
  volume={66 1},
  pages={425-8}
}
Opioids have been found to modulate the immune system by regulating the function of immunocompetent cells. Several studies suggest that the interaction between immune and opioid systems is not unidirectional, but rather reciprocal, in nature. In the CNS, one cellular target of immune system activation is the astrocytes. These glial cells have been shown to produce the opioid peptide, proenkephalin, to express the mu-, delta-, and kappa-opioid receptors, and to respond to the immune factor… CONTINUE READING