Interleukin-1 beta mRNA expression in ischemic rat cortex.

  title={Interleukin-1 beta mRNA expression in ischemic rat cortex.},
  author={T Liu and Peter C. McDonnell and Peter R. Young and Raymond F. White and A. L. Sir{\'e}n and John M. Hallenbeck and Frank Barone and G Z Feurestein},
  volume={24 11},
  pages={1746-50; discussion 1750-1}
BACKGROUND AND PURPOSE Interleukin-1 beta is a proinflammatory cytokine produced by blood-borne and resident brain inflammatory cells. The present study was conducted to determine if interleukin-1 beta mRNA was produced in the brain of rats subjected to permanent focal ischemia. METHODS Rat interleukin-1 beta cDNA, synthesized from stimulated rat peritoneal macrophage RNA by reverse transcription and polymerase chain reaction and cloned in plasmid Bluescript KS+, was used to evaluate the… CONTINUE READING


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