Interleukin-1 beta is a potent inhibitor of bone formation in vitro.

  title={Interleukin-1 beta is a potent inhibitor of bone formation in vitro.},
  author={Philip P. Stashenko and Floyd E. Dewhirst and M L Rooney and L A Desjardins and John D. Heeley},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={2 6},
The effect of interleukin-1 beta, the major component of osteoclast-activating factor (OAF), on bone formation by fetal rat osteoblast-rich cells was investigated. An in vitro culture system developed by Ecarot-Charrier et al. (1983) and Bellows et al. (1986) was utilized in which osteoblasts form mineralized nodules which closely resemble woven bone. Continuous exposure of cultures to homogenous IL-1 beta resulted in potent inhibition of mineralized nodule formation, which was half maximal at… CONTINUE READING


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