Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus.

@article{Bellinger1993Interleukin1B,
  title={Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus.},
  author={Frederick P Bellinger and Samuel G. Madamba and George Robert Siggins},
  journal={Brain research},
  year={1993},
  volume={628 1-2},
  pages={227-34}
}
Cytokines such as interleukin-1 beta (IL-1 beta) are released in the nervous system following inflammation or infection. Recently, IL-1 beta was shown to enhance synaptic inhibitory mechanisms. We therefore investigated the effect of IL-1 beta superfusion on long-term potentiation (LTP), the cellular model of memory and learning, evoked in the CA1 region by tetanic stimulation of the stratum radiatum in the rat hippocampal slice. IL-1 beta (150 pM-1.5 nM) superfused 10 min before tetanic… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS