Interleukin-1 beta guides the migration of cortical neurons

  title={Interleukin-1 beta guides the migration of cortical neurons},
  author={Lei Ma and Xiaowei Li and Shi-jun Zhang and Feng Yang and Ge-min Zhu and Xiao-bing Yuan and Wen Shan Jiang},
  booktitle={Journal of Neuroinflammation},
Proinflammatory cytokine interleukin-1beta (IL-1β) is expressed at high levels in the developing brain and declines to low constitutive levels in the adult. However, the pathophysiological function of IL-1β during brain development remains elusive. In this study, we investigated the role of IL-1β in neuronal migration. The Boyden transwell assay was used to examine the effects of IL-1β on the migration of dissociated primary cortical neurons. To determine the role of IL-1β in neuron leading… CONTINUE READING
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