Interleukin-1 beta differentially represses drug-metabolizing enzymes in arthritic female rats.

@article{Ferrari1993Interleukin1BD,
  title={Interleukin-1 beta differentially represses drug-metabolizing enzymes in arthritic female rats.},
  author={L. E. Ferrari and J. Y. Jouzeau and Pierre Gillet and R{\'e}gine Herber and P. Fener and A. M. Batt and Patrick Netter},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={264 2},
  pages={1012-20}
}
Experimental arthritis and inflammation have been reported to reduce liver cytochrome P-450-dependent mono-oxygenase activities with subsequent impairment of drug metabolism. Interleukin-1 beta (IL-1) is among the proven mediators of both inflammation and P-450 decrease, although some paradoxical effects were sometimes reported in experimental models of arthritis. The aim of the present study was to evaluate the main liver drug-metabolizing isoenzymes during established collagen-induced… CONTINUE READING