Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells.

@article{Kondo1995Interleukin1BE,
  title={Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells.},
  author={Seiji Kondo and Barbara P. Barna and Tatsuo Morimura and Juji Takeuchi and Jianling Yuan and Aytac Akbasak and Gene H. Barnett},
  journal={Cancer research},
  year={1995},
  volume={55 24},
  pages={6166-71}
}
Increasing the susceptibility of tumor cells to apoptotic cell death following chemotherapy is of importance to the outcome of cancer treatment. Although the tumor suppressor gene p53 is required for efficient induction of apoptosis by chemotherapeutic agents, it is not the only apoptosis mediator gene. The molecular mechanisms mediating apoptosis following chemotherapy via p53-dependent or p53-independent pathways remain unclear. We show here that cis-diamminedichloroplatinum (cisplatin… CONTINUE READING
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