Interleukin-1 beta causes the increase in anterior hypothalamic interleukin-6 during LPS-induced fever in rats.

@article{Klr1994Interleukin1BC,
  title={Interleukin-1 beta causes the increase in anterior hypothalamic interleukin-6 during LPS-induced fever in rats.},
  author={Jan Kl{\'i}r and John L. McClellan and Matthew Jay Kluger},
  journal={The American journal of physiology},
  year={1994},
  volume={266 6 Pt 2},
  pages={R1845-8}
}
The purpose of this study was to determine, using push-pull perfusion, whether the central pyrogenic action of interleukin-6 (IL-6) during lipopolysaccharide (LPS)-induced fever in rats is induced by interleukin-1 beta (IL-1 beta) and to determine the source of the hypothalamic IL-6 (i.e., from the periphery or from the brain). Samples of cerebrospinal fluid were collected 60 min before and 60, 120, 180, and 240 min after the intraperitoneal injection of LPS or saline as a control. Immediately… CONTINUE READING

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