Interleukin-1 beta and tumor necrosis factor alpha inhibit migration activity of chondrogenic progenitor cells from non-fibrillated osteoarthritic cartilage

@inproceedings{Joos2013Interleukin1BA,
  title={Interleukin-1 beta and tumor necrosis factor alpha inhibit migration activity of chondrogenic progenitor cells from non-fibrillated osteoarthritic cartilage},
  author={Helga Joos and Anja Wildner and Cathrin Hogrefe and Heiko Reichel and Rolf E Brenner},
  booktitle={Arthritis research & therapy},
  year={2013}
}
INTRODUCTION The repair capability of traumatized articular cartilage is highly limited so that joint injuries often lead to osteoarthritis. Migratory chondrogenic progenitor cells (CPC) might represent a target cell population for in situ regeneration. This study aims to clarify, whether 1) CPC are present in regions of macroscopically intact cartilage from human osteoarthritic joints, 2) CPC migration is stimulated by single growth factors and the cocktail of factors released from traumatized… CONTINUE READING

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