Interleukin-1 b Inhibits g-Aminobutyric Acid Type A ( GABAA ) Receptor Current in Cultured Hippocampal Neurons

@inproceedings{Wang2000Interleukin1BI,
  title={Interleukin-1 b Inhibits g-Aminobutyric Acid Type A ( GABAA ) Receptor Current in Cultured Hippocampal Neurons},
  author={Sam Wang and Qing Cheng and Sundeep Malik and Jay Ming-Che Yang},
  year={2000}
}
Interleukin-1b (IL-1b), a polypeptide immune mediator, is induced within the central nervous system in response to a variety of pathological stimuli, including systemic infection, hypoxia, brain trauma, and seizure. IL-1b action on the g-aminobutyric acid type A (GABAA) inhibitory neurotransmitter receptor was investigated in whole cell patch-clamped cultured hippocampal neurons. Application of IL-1b at concentrations encountered in pathophysiological conditions (1–10 ng/ml; 59– 590 pM… CONTINUE READING