Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.

  title={Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.},
  author={L. G. Miller and Wendy R. Galpern and Kathleen Dunlap and Charles Anthony Dinarello and T. John Turner},
  journal={Molecular pharmacology},
  volume={39 2},
Interleukin-1 (IL-1), a cytokine involved in the acute phase reaction to injury and infection, has multiple effects in the central nervous system, including induction of fever and sleep and the release of several neuropeptides. We evaluated effects of IL-1 beta on inhibitory postsynaptic function at the gamma-aminobutyric acidA (GABAA) receptor. IL-1 (100 pg/ml to 10 ng/ml) augmented GABAA receptor function in cortical synaptic preparations. This effect of IL-1 was largely prevented by… CONTINUE READING