Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.

@article{Buchan1988Interleukin1AT,
  title={Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.},
  author={Glenn Buchan and Kathy Barrett and Martin Turner and David Chantry and Ravinder N. Maini and Marc Feldmann},
  journal={Clinical and experimental immunology},
  year={1988},
  volume={73 3},
  pages={449-55}
}
In rheumatoid arthritis there is a chronic immune and inflammatory reaction which can lead to the destruction of the diseased joint. Cytokine gene expression was studied in synovial cells using cDNA probes specific for human interleukin 1 (IL-1), -alpha and IL-1 beta, tumour necrosis factor (TNF), -alpha and TNF beta (lymphotoxin); protein molecules which induce cartilage degradation and bone resorption. In all cases studied, IL-1 mRNA was present in freshly isolated synovial cells from fluid… CONTINUE READING