Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis.

@article{Guzeldemir2008Interleukin1AT,
  title={Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis.},
  author={Esra Guzeldemir and Meral Gunhan and Onur Ozcelik and Hakki Taştan},
  journal={Journal of oral science},
  year={2008},
  volume={50 2},
  pages={151-9}
}
Localized aggressive periodontitis (LAgP) is a complex multifactorial periodontal disease to which genetic factors are thought to predispose individuals. Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are potent immunomodulators and proinflammatory cytokines that have been implicated in the pathogenesis of autoimmune and infectious diseases and proposed to be risk factors for LAgP. Our aim was to investigate IL-1 alpha (+4845), IL-1 beta (+3954), and TNF-alpha (-308) gene… CONTINUE READING

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Association between Interleukin-1β Gene −511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis

Medical science monitor : international medical journal of experimental and clinical research • 2015
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