Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells

@article{Emeis1986Interleukin1A,
  title={Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells},
  author={J. Emeis and T. Kooistra},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={163},
  pages={1260 - 1266}
}
  • J. Emeis, T. Kooistra
  • Published 1986
  • Biology, Medicine
  • The Journal of Experimental Medicine
  • Human IL-1, recombinant murine IL-1 and E. coli LPS were found to be potent inducers of plasminogen activator (PA)-inhibitor activity, both in vivo, in rats, as well as in cultured human endothelial cells. In vivo, LPS rapidly and dose-dependently (0.01-1,000 micrograms/kg) increased plasma PA-inhibitor activity. Infusion of IL-1 into rats resulted in a small but significant increase in PA-inhibitor activity in rat plasma. Likewise, in cultured human umbilical vein endothelial cells, LPS and IL… CONTINUE READING

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