Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

@article{Bevilacqua1985Interleukin1A,
  title={Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.},
  author={Michael P. Bevilacqua and Jordan S Pober and Malcolm E. Wheeler and Ramzi S. Cotran and Michael A. Gimbrone},
  journal={The Journal of clinical investigation},
  year={1985},
  volume={76 5},
  pages={2003-11}
}
Increased leukocyte adhesion to the endothelial lining of blood vessels is an essential event in inflammation and the pathogenesis of certain vascular diseases. We have studied the effect of interleukin 1 (IL-1), an inflammatory/immune mediator, on endothelial-leukocyte adhesion using quantitative in vitro assays. Selective pretreatment of cultured human umbilical vein endothelial monolayers with IL-1 (5 U/ml, 4 h) resulted in an 18.3 +/- 2.6-fold increase in human peripheral blood… CONTINUE READING

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