Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma.

@article{Kawano1989Interleukin1AA,
  title={Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma.},
  author={Makoto Kawano and Hiroki Tanaka and Hideaki Muroishi Ishikawa and Masaharu Nobuyoshi and Kohji Iwato and Hideki Asaoku and Osamu Tanabe and Atsushi Kuramoto},
  journal={Blood},
  year={1989},
  volume={73 8},
  pages={2145-8}
}
Recombinant interleukin 1 alpha (rIL-1 alpha) augmented proliferation of freshly isolated myeloma cells as well as B-cell stimulatory factor 2 (BSF-2)/interleukin-6 (IL-6). Recombinant IL-1 alpha-induced proliferation was partially inhibited by anti-IL-6 antibody. In the culture supernatants of rIL-1 alpha-stimulated myeloma cells, IL-6 activities, which were measured by using an IL-6-dependent murine hybridoma clone, MH60.BSF2, were increased, when compared with those in the culture… CONTINUE READING

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