Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding

@article{Chamberlain2009Interleukin1RM,
  title={Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding},
  author={Janet Chamberlain and Sheila E Francis and Zo{\"e} L. S. Brookes and Gary Shaw and Delyth Graham and Nicholas J. Alp and Steven K. Dower and David C. Crossman},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={2455 - 2464}
}
BACKGROUND Atherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet. However, the interplay between diet, inflammatory mechanisms and vascular risk factors requires further research. We hypothesised that interleukin-1 (IL-1) signaling in the vessel wall would raise arterial blood pressure and promote atheroma. METHODOLOGY/PRINCIPAL FINDINGS Apoe(-/-) and Apoe(-/-)/IL-1R1(-/-) mice were fed… CONTINUE READING