Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial.

@article{Shakoory2016Interleukin1RB,
  title={Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial.},
  author={Bita Shakoory and Joseph Carcillo and W. Winn Chatham and Richard L. Amdur and Huaqing Zhao and Charles A Dinarello and Randy Quentin Cron and Steven M. Opal},
  journal={Critical care medicine},
  year={2016},
  volume={44 2},
  pages={275-81}
}
OBJECTIVE To determine the efficacy of anakinra (recombinant interleukin-1 receptor antagonist) in improving 28-day survival in sepsis patients with features of macrophage activation syndrome. Despite equivocal results in sepsis trials, anakinra is effective in treating macrophage activation syndrome, a similar entity with fever, disseminated intravascular coagulation, hepatobiliary dysfunction, cytopenias, and hyperferritinemia. Hence, sepsis patients with macrophage activation syndrome… CONTINUE READING
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