Interleukin-1 Receptor-Associated Kinase M-Deficient Mice Demonstrate an Improved Host Defense during Gram-negative Pneumonia

@article{Hoogerwerf2012Interleukin1RK,
  title={Interleukin-1 Receptor-Associated Kinase M-Deficient Mice Demonstrate an Improved Host Defense during Gram-negative Pneumonia},
  author={Jacobien J. Hoogerwerf and Gerritje J. W. van der Windt and Dana C. Blok and Arie J. Hoogendijk and Alex F. de Vos and Cornelis van’t Veer and Sandrine Florquin and Koichi S Kobayashi and Richard A Flavell and Tom van der Poll},
  journal={Molecular Medicine},
  year={2012},
  volume={18},
  pages={1067-1075}
}
Pneumonia is a common cause of morbidity and mortality and the most frequent source of sepsis. Bacteria that try to invade normally sterile body sites are recognized by innate immune cells through pattern recognition receptors, among which toll-like receptors (TLRs) feature prominently. Interleukin-1 receptor (IL-1R)-associated kinase (IRAK)-M is a proximal inhibitor of TLR signaling expressed by epithelial cells and macrophages in the lung. To determine the role of IRAK-M in host defense… CONTINUE READING

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VIEW 1 EXCERPT
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References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Critical role of IL-1 receptorassociated kinase-M in regulating chemokinedependent deleterious inflammation in murine influenza pneumonia

  • M Seki
  • J. Immunol
  • 2010
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Critical role of IL - 1 receptor - associated kinase - M in regulating chemokine - dependent deleterious inflammation in murine influenza pneumonia . J . Immunol

  • R LeGoffic
  • 2010