Interleukin-1 B and Interleukin-1 Receptor Antagonist Gene Polymorphisms and Gastric Cancer : A Meta-analysis

  title={Interleukin-1 B and Interleukin-1 Receptor Antagonist Gene Polymorphisms and Gastric Cancer : A Meta-analysis},
  author={M Constanza Camargo and Robertino M. Mera and Pelayo Correa and Richard M Peek and Elizabeth T. H. Fontham and Karen Jean Goodman and M Blanca Piazuelo and Liviu A Sicinschi and Jovanny Zabaleta and Barbara G. Schneider},
Background: Polymorphisms of interleukin-1B (IL1B) and its receptor antagonist (IL1RN) genes have been inconsistently associated with gastric cancer risk. We examined these associations by performing meta-analyses. Materials and Methods: Twenty-five studies testing the association between IL1B and/or IL1RN gene polymorphisms and gastric cancer were examined: 14 studies of IL1B-511 , 14 studies of IL1B-31 , 8 studies of IL1B+3954 , and 23 studies of IL1RN. Overall and ethnicity-specific summary… CONTINUE READING


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