Interleukin-1 (IL-1) Pathway
@article{Weber2010Interleukin1P, title={Interleukin-1 (IL-1) Pathway}, author={Axel Weber and Peter Wasiliew and Michael Kracht}, journal={Science Signaling}, year={2010}, volume={3}, pages={cm1 - cm1} }
IL-1α and IL-1β orchestrate the proinflammatory response by multiple tightly controlled mechanisms. The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a number of human autoinflammatory diseases. IL-1…
672 Citations
IL-1 receptor 2 (IL-1R2) and its role in immune regulation
- Biology, MedicineBrain, Behavior, and Immunity
- 2013
A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases.
- BiologySelf/nonself
- 2011
IL-1 cytokine family plays a key role in the innate immune response against pathogen- and danger-associated molecular patterns. More recently, IL-1 receptor type 1 (IL-R1) signaling has been…
ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.
- BiologyCytokine
- 2015
PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis
- Biology, MedicineThe Journal of Biological Chemistry
- 2019
PAS–IL-1Ra is validated as an active IL-1 antagonist with marked in vivo potency and a significantly extended half-life compared with anakinra.
Interleukin 1 alpha (IL-1α) restricts Brucella abortus 544 survival through promoting lysosomal-mediated killing and NO production in macrophages.
- BiologyVeterinary microbiology
- 2019
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.
- Biology, MedicineBlood
- 2011
This review summarizes acute and chronic inflammatory diseases that are treated by reducing IL-1β activity and proposes that disease severity is affected by the anti-inflammatory members of the IL- 1 family of ligands and receptors.
Interleukin-18 and IL-18 Binding Protein
- Biology, MedicineFront. Immunol.
- 2013
The biology of IL-18 is reviewed as well as its role in human disease, which has been implicated in several autoimmune diseases, myocardial function, emphysema, metabolic syndromes, psoriasis, inflammatory bowel disease, hemophagocytic syndrome, macrophage activation syndrome, sepsis, and acute kidney injury.
IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells
- BiologyThe Journal of Immunology
- 2019
A novel IL-1β dependent pathway for secretion of the antimicrobial peptide IL-26 from human Th17 cells that is independent of and more rapid than classical TCR activation is described.
References
SHOWING 1-10 OF 160 REFERENCES
Biologic basis for interleukin-1 in disease.
- Biology, MedicineBlood
- 1996
This is a lengthy review, with 586 citations chosen to illustrate specific areas of interest rather than a compendium of references, which summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease.
The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)*
- BiologyThe Journal of Biological Chemistry
- 1997
IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL- 1-dependent activation of transcription factors and gene expression.
Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1β
- Biology, ChemistryNature
- 1997
The crystal structure shows that s-IL1R consists of three immunoglobulin-like domains which wrap around IL-1β in a manner distinct from the structures of previously described cytokine–receptor complexes.
Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes.
- Biology, MedicineBlood
- 1992
IL-1ra inhibits IL-1-induced cytokine synthesis and competes with IL-3 for the IL- 1RtII on human monocytes, suggesting a prolonged presence of IL-2 or restimulation of IL -1 receptors on monocytes is required for the induction of cytokines.
Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide
- BiologyMolecular and Cellular Biology
- 2006
Tollip controls the magnitude of inflammatory cytokine production in response to IL-1β and LPS, and the production of the proinflammatory cytokines, IL-6 and tumor necrosis factor alpha was significantly reduced after IL- 1β andLPS treatment at low doses but not at lethal doses of LPS.
Intracellular Trafficking of Interleukin-1 Receptor I Requires Tollip
- BiologyCurrent Biology
- 2006
IL‐1, IL‐18, and IL‐33 families of cytokines
- Biology, MedicineImmunological reviews
- 2008
Summary: The interleukin‐1 (IL‐1), IL‐18, and IL‐33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized. All three cytokines are…
Immunological and inflammatory functions of the interleukin-1 family.
- BiologyAnnual review of immunology
- 2009
The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
- BiologyNature Cell Biology
- 2000
It is shown that, before IL-1β treatment, Tollip is present in a complex with IRAK, and that recruitment of Tollip–IRAK complexes to the activated receptor complex occurs through association of tollip with IL- 1RAcP, and it is concluded that tollip is an important constituent of theIL-1R signalling pathway.
Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway
- Biology, ChemistryMolecular and Cellular Biology
- 2001
It is suggested that IRAK regulates the redistribution of TAB2 upon IL-1 stimulation and facilitates the formation of a TRAF6-TAB2-TAK1 complex, which is an essential step in the activation of TAK1 in theIL-1 signaling pathway.