Interleukin-1 (IL-1) Pathway

  title={Interleukin-1 (IL-1) Pathway},
  author={Axel Weber and Peter Wasiliew and Michael Kracht},
  journal={Science Signaling},
  pages={cm1 - cm1}
IL-1α and IL-1β orchestrate the proinflammatory response by multiple tightly controlled mechanisms. The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a number of human autoinflammatory diseases. IL-1… 
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Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes.
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