Interleukin-1 (IL-1) Pathway

@article{Weber2010Interleukin1P,
  title={Interleukin-1 (IL-1) Pathway},
  author={A. Weber and P. Wasiliew and M. Kracht},
  journal={Science Signaling},
  year={2010},
  volume={3},
  pages={cm1 - cm1}
}
IL-1α and IL-1β orchestrate the proinflammatory response by multiple tightly controlled mechanisms. The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a number of human autoinflammatory diseases. IL-1… Expand
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References

SHOWING 1-10 OF 160 REFERENCES
Biologic basis for interleukin-1 in disease.
  • 4,194
  • PDF
Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide
  • 183
  • PDF
Intracellular Trafficking of Interleukin-1 Receptor I Requires Tollip
  • 112
IL‐1, IL‐18, and IL‐33 families of cytokines
  • 719
Immunological and inflammatory functions of the interleukin-1 family.
  • C. Dinarello
  • Biology, Medicine
  • Annual review of immunology
  • 2009
  • 2,670
  • Highly Influential
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
  • 526
  • PDF
...
1
2
3
4
5
...