Interleukin-1 (IL-1alpha and IL-1beta) and its receptors (IL-1RI, IL-1RII, and IL-1Ra) in prostate carcinoma.

  title={Interleukin-1 (IL-1alpha and IL-1beta) and its receptors (IL-1RI, IL-1RII, and IL-1Ra) in prostate carcinoma.},
  author={M{\'o}nica Ricote and Ignacio Garc{\'i}a-Tu{\~n}{\'o}n and Ferm{\'i}n R. De Bethencourt and Benito Fraile and Ricardo Alfaro Paniagua and Mar Royuela},
  volume={100 7},
BACKGROUND The principal components of the interleukin-1 (IL-1) family are two secreted factors (IL-1alpha and IL-1beta), two transmembrane receptors (IL-1RI [biologically active] and IL-1RII [inert receptor]), and a natural antagonist receptor of IL-1 function (IL-1Ra). Changes in the expression pattern of these IL-1 members have been reported to be related to disease progression. The objective of the current study was to evaluate these changes in prostatic tissue by means of… CONTINUE READING


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