Interleukin 1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro.

@article{VidalVanaclocha1996Interleukin1,
  title={Interleukin 1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro.},
  author={Fernando Vidal-Vanaclocha and Aaron Alvarez and Aintzane Asumendi and B. Urcelay and Paola Tonino and Charles A Dinarello},
  journal={Journal of the National Cancer Institute},
  year={1996},
  volume={88 3-4},
  pages={198-205}
}
BACKGROUND The growth of cancer cells in inflammatory tissue is often observed. This can be the result of favorable conditions for endothelial cell adherence and/or increased production of local growth factors. PURPOSE The role of the proinflammatory cytokine interleukin 1 (IL-1) in the prometastatic and growth-promoting environment of inflammation was studied in vivo, and the mechanism of cytokine action was studied in vitro as well. METHODS Systemic inflammation was induced by the… CONTINUE READING
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