Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

@inproceedings{Gui2016Interleukin1OI,
  title={Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents},
  author={Wen-Shan Gui and Xiao Wei and C. Mai and Madhuvika Murugan and Long-Jun Wu and Wen-Jun Xin and Li-Jun Zhou and Xian-guo Liu},
  booktitle={Molecular pain},
  year={2016}
}
BACKGROUND Chronic pain is often accompanied by short-term memory deficit and depression. Currently, it is believed that short-term memory deficit and depression are consequences of chronic pain. Here, we test the hypothesis that the symptoms might be caused by overproduction of interleukin-1beta (IL-1β) in the injured nerve independent of neuropathic pain following spared nerve injury in rats and mice. RESULTS Mechanical allodynia, a behavioral sign of neuropathic pain, was not correlated… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 79 REFERENCES

Activation of corticostriatal circuitry relieves chronic neuropathic pain.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2015
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL