Interleukin-1β interferes with epidermal homeostasis through induction of insulin resistance: implications for psoriasis pathogenesis.

@article{Buerger2012Interleukin1IW,
  title={Interleukin-1β interferes with epidermal homeostasis through induction of insulin resistance: implications for psoriasis pathogenesis.},
  author={Claudia Buerger and Beatrice Richter and Kathrin Woth and Rebekka Salgo and Bartosz Malisiewicz and Sandra Diehl and Katja Hardt and Sandra Boehncke and W. -H. Boehncke},
  journal={The Journal of investigative dermatology},
  year={2012},
  volume={132 9},
  pages={
          2206-14
        }
}
Response pathways of the metabolic and the immune system have been evolutionary conserved, resulting in a high degree of integrated regulation. Insulin is a central player in the metabolic system and potentially also in the homeostasis of the skin. Psoriasis is a frequent and often severe autoimmune skin disease, clinically characterized by altered epidermal homeostasis, of which the molecular pathomechanisms are only little understood. In this study, we have examined a potential role for… CONTINUE READING
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