Interleukin-1β induces angiogenesis and innervation in human intervertebral disc degeneration.

  title={Interleukin-1β induces angiogenesis and innervation in human intervertebral disc degeneration.},
  author={Jae Man Lee and Ji Ye Song and Minjung Baek and Hye-Young Jung and Haeyoun Kang and In Bo Han and Young Do Kwon and Dong Eun Shin},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={29 2},
Degenerative disorders of the intervertebral discs (IVDs) are generally characterized by enhanced matrix degradation, angiogenesis, innervation, and increased expression of catabolic cytokines. In this study, we investigated the effects of inflammatory cytokines, IL-1β, and TNF-α, on the expression of an angiogenic factor, vascular endothelial growth factor (VEGF), and neurotrophic factors, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), in human IVD degeneration. IL-1… CONTINUE READING
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