Interleukin-1β-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and α-melanocyte-stimulating hormone prevented these effects

@article{Machado2015Interleukin1inducedMR,
  title={Interleukin-1β-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and α-melanocyte-stimulating hormone prevented these effects},
  author={Ivana Machado and Patricia C. Gonz{\'a}lez and Alejandro Vilcaes and Lila Carniglia and Teresa N Scimonelli},
  journal={Brain, Behavior, and Immunity},
  year={2015},
  volume={46},
  pages={137-146}
}
The immune system is an important modulator of learning, memory and neural plasticity. Interleukin 1β (IL-1β), a pro-inflammatory cytokine, significantly affects several cognitive processes. Previous studies by our group have demonstrated that intrahippocampal administration of IL-1β impairs reconsolidation of contextual fear memory. This effect was reversed by the melanocortin alpha-melanocyte-stimulating hormone (α-MSH). The mechanisms underlying the effect of IL-1β on memory reconsolidation… CONTINUE READING

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