Interleukin-1β down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes

@article{Aronica2005Interleukin1DT,
  title={Interleukin-1β down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes},
  author={Eleonora Aronica and Jan A. Gorter and Annemieke J.M. Rozemuller and Bulent Yankaya and Dirk Troost},
  journal={Journal of Neuroimmunology},
  year={2005},
  volume={160},
  pages={188-194}
}
Expression of metabotropic glutamate receptor 5 (mGluR5) protein is known to be plastic and to depend critically on the astrocytes' microenvironment. In the present study we investigated whether interleukins, which are involved in the immune response following brain injury, could contribute to the regulation of mGluR5 protein in human astrocytes in culture. Using Western blotting and immunocytochemistry, no detectable changes in the expression of the mGluR5 protein were observed with both… CONTINUE READING

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