Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse.

@article{Toldo2013Interleukin1BI,
  title={Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse.},
  author={Stefano Toldo and Eleonora Mezzaroma and Benjamin W Van Tassell and Daniela Farkas and Carlo Marchetti and Norbert Felix Voelkel and Antonio Abbate},
  journal={Experimental physiology},
  year={2013},
  volume={98 3},
  pages={
          734-45
        }
}
The formation of the cryopyrin inflammasome in the heart induces an intense inflammatory response during acute myocardial infarction (AMI), which mediates further damage and promotes adverse cardiac remodelling. Active interleukin-1β (IL-1β) is a key product of the inflammasome, being cleaved by active caspase-1. The aim of this study was to dissect the role of IL-1β from that of the inflammasome by using a neutralizing monoclonal antibody directed against IL-1β and measuring the intensity of… CONTINUE READING
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