Interleukin-1β Receptor Antagonism Prevents Cognitive Impairment Following Experimental Bacterial Meningitis.

Abstract

Pneumococcal meningitis is characterized by high rates of mortality and long-term cognitive impairment. In this study, we evaluated the effects of interleukin (IL)-1β receptor antagonist (IL-1Ra) on memory, cytokine, and brain-derived neurotrophic factor (BDNF) levels in hippocampus after experimental pneumococcal meningitis. In a first experiment the… (More)

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Cite this paper

@article{Barichello2015Interleukin1RA, title={Interleukin-1β Receptor Antagonism Prevents Cognitive Impairment Following Experimental Bacterial Meningitis.}, author={Tatiana Barichello and Jaqueline S Generoso and Lutiana Roque Sim{\~o}es and Vladislav G Sharin and Renan Antonio Ceretta and Diogo Dominguini and Clarissa Martinelli Comim and M{\'a}rcia de Carvalho Vilela and Antonio Lucio Teixeira and J. Quevedo}, journal={Current neurovascular research}, year={2015}, volume={12 3}, pages={253-61} }