Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's Disease.

@article{Yin2016Interleukin1PP,
  title={Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's Disease.},
  author={Y. Q. Yin and Yan Liu and Xiao Pan and Rui Chen and Peng Li and H S Wu and Zheng-Qing Zhao and Yanpeng Li and Liu-Qing Huang and Jian-hua Zhuang and Zhong-xin Zhao},
  journal={PloS one},
  year={2016},
  volume={11 3},
  pages={e0149945}
}
Sleep alleviates Alzheimer's disease (AD)-related neuropathological processes, whereas sleep disturbance in AD patients is associated with elevated peripheral inflammatory cytokine levels. In the present study, we assessed interleukin (IL)-1β and APOEε4 polymorphisms for association with susceptibility of sleep disturbances in AD patients. A total of 123 pretreated AD patients and 120 age-, gender- and education level-matched healthy controls were recruited for two consecutive full-night… CONTINUE READING