Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells

@inproceedings{BertinMaghit2011Interleukin1PI,
  title={Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells},
  author={Sebastien Bertin-Maghit and Dimeng Pang and Brendan John O'Sullivan and Shannon E. Best and Emily G Duggan and Sanjoy K Paul and Helen E. Thomas and Thomas W H Kay and Leonard C. Harrison and Raymond J Steptoe and Ranjeny Thomas},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE The effectiveness of tolerizing immunotherapeutic strategies, such as anti-CD40L or dendritic cells (DCs), is greater when administered to young nonobese diabetic (NOD) mice than at peak insulitis. RelB(lo) DCs, generated in the presence of an nuclear factor-κB inhibitor, induce T-regulatory (Treg) cells and suppress inflammation in a model of rheumatoid arthritis. Interleukin (IL)-1β is overexpressed in humans and mice at risk of type 1 diabetes, dysregulates Treg cells, and… CONTINUE READING
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in NOD mice

  • MG Netea, N Hancu, +4 authors JW vanderMeer
  • 2009

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