Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma.

@article{Doucet1998Interleukin4,
  title={Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma.},
  author={Christelle Doucet and Dani{\`e}le Brouty-Boy{\'e} and Corinne Pottin-Clemenceau and Giorgio Walter Canonica and Claude Jasmin and Bruno Azzarone},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 10},
  pages={2129-39}
}
Airway hyperresponsiveness leading to subepithelial fibrosis is mediated by inflammatory cells activated by T helper (Th) 2-derived cytokines such as IL-4 and IL-5. By analyzing the phenotype and response of human lung fibroblasts derived from either fetal (ICIG7) or adult (CCL202) tissue as well as from a Th2-type stromal reaction (FPA) to IL-4 and IL-13, we provide evidence that human lung fibroblasts may behave as inflammatory cells upon activation by IL-4 and IL-13. We show that the three… CONTINUE READING
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