Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans.

@article{MacLennan2004InterleukinA,
  title={Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans.},
  author={Calman A MacLennan and Claire Fieschi and D. Anthony Lammas and Capucine Picard and Susan E. Dorman and Ozden Sanal and Jenny M Maclennan and Steven M Holland and Tom H. M. Ottenhoff and J. Hugo P{\'e}rez Casanova and Dinakantha Kumararatne},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={190 10},
  pages={1755-7}
}
Patients with inherited deficiency of the interleukin (IL)-12/IL-23-interferon (IFN)- gamma axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/IL-23-component deficiency had a history of salmonella disease than did those with IFN- gamma -component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by… CONTINUE READING