Interleukin‐8, a chemotactic and inflammatory cytokine

@article{Baggiolini1992Interleukin8AC,
  title={Interleukin‐8, a chemotactic and inflammatory cytokine},
  author={Marco Baggiolini and I Clark-lewis},
  journal={FEBS Letters},
  year={1992},
  volume={307}
}
Interleukin‐8 (IL‐8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin‐1 or tumor necrosis factor) and activates neutrophils inducing, chemotaxis, exocytosis and the respiratory burst. In vivo, IL‐8 elicits a massive neutrophil accumulation at the site of injection. Five neutrophil‐activating cytokines similar to IL‐8 in structure and function have been… 
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The study shows that stimulation of PMNs with LPS leads to induction of IL-8R expression enhancing theIL-8-mediated biological responses and provides evidence for post-stimulatory restoration of receptor level on the neutrophil surface by proteolytic cleavage of the amino-terminal end of the receptor.
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TLDR
It is concluded that PAF activates neutrophils, either directly or by promoting the production of TNF‐α and CINC, and is involved in hepatic IR injury.
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