Interleukin‐13 in the skin and interferon‐γ in the liver are key players in immune protection in human schistosomiasis

  title={Interleukin‐13 in the skin and interferon‐$\gamma$ in the liver are key players in immune protection in human schistosomiasis},
  author={Alain Dessein and Bour{\'e}ma Kouriba and Carole Eboumbou and Hélia Dessein and Laurent Argiro and Sandrine Marquet and Nasr Eldin Elwali and Virmondes Rodrigues and Yuesheng Li and Ogobara K. Doumbo and Christophe Chevillard},
  journal={Immunological Reviews},
Summary:  Immunity against schistosomes includes anti‐infection immunity, which is mainly active against invading larvae in the skin, and anti‐disease immunity, which controls abnormal fibrosis in tissues invaded by schistosome eggs. Anti‐infection immunity is T‐helper 2 (Th2) cell‐dependent and is controlled by a major genetic locus that is located near the Th2 cytokine locus on chromosome 5q31‐q33. Mutations in the gene encoding interleukin (IL)‐13 that decrease or increase IL‐13 production… 
Circulating cytokine levels and antibody responses to human Schistosoma haematobium: IL-5 and IL-10 levels depend upon age and infection status
A mixed Th1/Th2 systemic environment occurs in people with patent schistosome infection, while a stronger Th2‐dominated suite of cytokines is evident in egg‐negative individuals.
Enhanced protection from fibrosis and inflammation in the combined absence of IL‐13 and IFN‐γ
It is demonstrated that by reducing compensatory increases in type 1‐associated inflammation, therapeutic strategies that block IFN‐γ and IL‐13 activity simultaneously can confer greater protection from progressive fibrosis thanIL‐13 blockade alone.
Human cytokine responses during natural and experimental exposure to parasitic helminth infection
Investigation of how cytokines, the molecular mediators of the immune system, can be used to characterise human immune phenotype during natural and experimental helminth infection found responses to the antigens of S. haematobium cercariae are more proinflammatory than those elicited by adult worms and eggs prior to treatment, reflecting the distinct proteomes and exposure patterns of the 3 life-cycle stages.
Resistance to liver fluke infection in the natural sheep host is correlated with a type‐1 cytokine response
These studies provide the first evidence to suggest that the induction of an early type‐1 immune response in this natural sheep host may be responsible for the ability to resist liver fluke infection.
Vaccine-Induced Protection Against Murine Schistosomiasis Mansoni with Larval Excretory–Secretory Antigens and Papain or Type-2 Cytokines
Improvement of ESP selection, singly or in a combination, and immunization regimen, namely ESP and type-2 cytokine dose and injection site and schedule, could lead to a sterilizing schistosomiasis vaccine in the foreseeable future.
Effect of Chemotherapy with Praziquantel on the Production of Cytokines and Morbidity Associated with Schistosomiasis Mansoni
The data suggest that chemotherapy is effective in reducing the morbidity of the disease and that the level of IL-13 may be a useful indicator of the persistence of fibrosis following treatment.
Type 1 innate lymphoid cells: Soldiers at the front line of immunity
The immune response to schistosome antigens in formerly infected travelers.
It is concluded that Schistosoma infection induced a memory immune response, and people who experienced KS tended to have a stronger immune response to schistosome antigens than their asymptomatic counterparts.


Cross‐regulatory role of interferon‐gamma (IFN‐γ), IL‐4 and IL‐10 in schistosome egg granuloma formation: in vivo regulation of Th activity and inflammation
Results support the notion of a cross‐regulatory network in which IFN inhibits Th2 and IL‐10 inhibits ThI cells in GR, whereas IFN contributes to enhanced GR macrophage function.
An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection
It is shown that sensitization with eggs plus IL-12 partly inhibits granuloma formation and dramatically reduces the tissue fibrosis induced by natural infection with Schistosoma mansoni worms, an example of a vaccine against parasites which acts by preventing pathology rather than infection.
Schistosoma‐specific helper T cell clones from subjects resistant to infection by Schistosoma mansoni are Th0/2
The results support previous conclusions on the role of IgE in protection against schistosomes in humans, and may indicate that IFN‐γ is required for full protection.
γ‐interferon treatment inhibits collagen deposition in murine schistosomiasis
A potential role for γ‐interferon as an antifibrogenic agent in vivo is indicated after an in vivo model of hepatic fibrogenesis, murine schistosomiasis.
Regulation and Function of the Interleukin 13 Receptor α 2 During a T Helper Cell Type 2–dominant Immune Response
IL-13 receptor (R)α2 is a critical down-regulatory factor of IL-13–mediated tissue fibrosis induced by the parasitic helminth Schistosoma mansoni, illustrating the central role played by the IL- 13Rα2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response.
IL-13 effector functions.
  • T. Wynn
  • Biology, Medicine
    Annual review of immunology
  • 2003
IL-13 was revealed as a potent mediator of tissue fibrosis in both schistosomiasis and asthma, which indicates that it is a key regulator of the extracellular matrix.
IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.
The data demonstrate that IL-12, initially described as an adjuvant for cell-mediated immunity, may be used to simultaneously to promote both humoral and cell- mediated protective responses against infection.
IFN-γ Polymorphisms (IFN-γ +2109 and IFN-γ +3810) Are Associated with Severe Hepatic Fibrosis in Human Hepatic Schistosomiasis (Schistosoma mansoni) 1
Observations support the view that IFN-γ expression and subsequent signal transduction play a critical role in the control of PPF in human hepatic schistosome infection (S. mansoni).
IL-13 and IFN-γ: Interactions in Lung Inflammation1
IFN-γ has double-sided effects (inhibiting some, potentiating others) on IL-13-induced changes in the lungs, which may be the reason for the ambiguous role of Th1 responses on Th2 response-induced lung injury.
Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection
A clear negative association between the proliferative responses to adult- and schistosomulum-stage antigens and subsequent reinfection intensity in older individuals (14 to 35 years) which was not present in the younger individuals (9 to 13 years).