Interleukin‐1‐induced activation of a protein kinase co‐precipitating with the type I interleukin‐1 receptor in T cells

@article{Martin1994Interleukin1inducedAO,
  title={Interleukin‐1‐induced activation of a protein kinase co‐precipitating with the type I interleukin‐1 receptor in T cells},
  author={Michael D. Martin and Gaby Fleur B{\"o}l and Anders Eriksson and Klaus Resch and Regina Brigelius-Flohé},
  journal={European Journal of Immunology},
  year={1994},
  volume={24}
}
We have investigated the possibility of a protein kinase participating in the signal transduction mechanisms of the interleukin‐1 (IL‐1) type I receptor (IL‐1RI). Our data show that a protein kinase was co‐precipitated with the IL‐1 RI from the two murine T helper cell lines D10N and EL‐4. The kinase activity was detected in an in vitro kinase assay performed with the immuno beads in the presence of exogenous substrates. IL‐1 treatment of the cells resulted in a rapid activation of this protein… 
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TLDR
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TLDR
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The remarkable conservation between diverse species indicates that the IL‐1 system represents an ancient signaling machine critical for responses to environmental stresses and attack by pathogens.
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