Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release.

@article{Dai2011InterlayercrosslinkedMW,
  title={Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release.},
  author={Jian Dai and Shudong Lin and Du Cheng and Seyin Zou and Xintao Shuai},
  journal={Angewandte Chemie},
  year={2011},
  volume={50 40},
  pages={9404-8}
}
Although the utilization of polymeric micelles has demonstrated great potential in delivering anticancer drugs, this technique is facing tremendous challenges. In particular, polymeric micelles usually show a drug-release profile that is not in favor of achieving optimal drug availability inside tumor cells. That is, a “burst release” of up to 20–30 % of the encapsulated drug within several hours post micelle formation, followed by a slow diffusional drug release lasting for many days. The… CONTINUE READING
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