Interlaboratory variation of biochemical markers of bone turnover.

  title={Interlaboratory variation of biochemical markers of bone turnover.},
  author={Markus J. Seibel and Martina Lang and W. J. Geilenkeuser},
  journal={Clinical chemistry},
  volume={47 8},
BACKGROUND Biochemical markers of bone metabolism are used to assess skeletal turnover, but the variability of marker assays is still an issue of practical concern. We describe the results of an international proficiency testing program for biochemical bone markers among clinical laboratories. METHODS Two serum and two urine pools (normal and increased marker concentrations) were sent on dry ice to 79 laboratories for analysis within 2 weeks of receipt. RESULTS Data were submitted by 73… CONTINUE READING


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