Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?

@article{EspinelIngroff2013InterlaboratoryVO,
  title={Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?},
  author={Ana Victoria Espinel-Ingroff and Maiken Cavling Arendrup and Michael A. Pfaller and Lucas Xavier Bonfietti and Beatriz Bustamante and Emilia Cant{\'o}n and Erja Chryssanthou and Manuel Cuenca-Estrella and Eric Dannaoui and Annette Fothergill and Jeff Fuller and Peter Gaustad and Gloria Mar{\'i}a Gonz{\'a}lez and Josep Guarro and Cornelia Lass-Fl{\"o}rl and Shawn R. Lockhart and Jacques F Meis and Caroline B. Moore and Luis L Ostrosky-Zeichner and Teresa Pel{\'a}ez and Sandra R.B.S. Pukinskas and Guy St-Germain and Maria Walderez Szeszs and John D. Turnidge},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 12},
  pages={5836-42}
}
Although Clinical and Laboratory Standards Institute (CLSI) clinical breakpoints (CBPs) are available for interpreting echinocandin MICs for Candida spp., epidemiologic cutoff values (ECVs) based on collective MIC data from multiple laboratories have not been defined. While collating CLSI caspofungin MICs for 145 to 11,550 Candida isolates from 17 laboratories (Brazil, Canada, Europe, Mexico, Peru, and the United States), we observed an extraordinary amount of modal variability (wide ranges… CONTINUE READING
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