Interlaboratory evaluation of endotoxin analyses in agricultural dusts--comparison of LAL assay and mass spectrometry.

@article{Reynolds2005InterlaboratoryEO,
  title={Interlaboratory evaluation of endotoxin analyses in agricultural dusts--comparison of LAL assay and mass spectrometry.},
  author={Stephen J. Reynolds and Donald K. Milton and Dick J. J. Heederik and Peter S Thorne and Kelley J. Donham and Elizabeth A Croteau and Kevin M. Kelly and Jeroen Douwes and Daniel B. Lewis and Mike Whitmer and Ian Connaughton and Sharon Koch and Per Malmberg and B Larsson and Jim A Deddens and Anita Saraf and L. Viktor Larsson},
  journal={Journal of environmental monitoring : JEM},
  year={2005},
  volume={7 12},
  pages={1371-7}
}
Endotoxin exposure is associated with wheeze and asthma morbidity, while early life exposure may reduce risk of allergy and asthma. Unfortunately, it is difficult to compare endotoxin results from different laboratories and environments. We undertook this study to determine if lipopolysaccharide (LPS) extraction efficiency could account for differences among laboratories. We generated and collected aerosols from chicken and swine barns, and corn processing. We randomly allocated side-by-side… CONTINUE READING