Interlaboratory comparison of short-term carcinogenicity studies using CB6F1-rasH2 transgenic mice.

@article{Takaoka2003InterlaboratoryCO,
  title={Interlaboratory comparison of short-term carcinogenicity studies using CB6F1-rasH2 transgenic mice.},
  author={Masaya Takaoka and Shinya Sehata and Takanori Maejima and Toshio Imai and Mikinori Torii and Hiroshi Satoh and Kaoru Toyosawa and Zen-yo Tanakamaru and Tamiko Adachi and Shigeru Hisada and Makoto Ueda and Hiroyuki Ogasawara and Masahiro Matsumoto and Kiyoshi Kobayashi and Mamoru Mutai and Toshimi Usui},
  journal={Toxicologic pathology},
  year={2003},
  volume={31 2},
  pages={191-9}
}
In order to evaluate a short-term carcinogenicity testing system using CB6F1 -Tg rasH2 (rasH2-Tg) mice carrying a human prototype c-Ha-ras gene, 26-week studies were conducted in 12 different facilities as a part of an International Life Science Institute Health and Environmental Science Institute (ILSI HESI) international collaborative project. In each study N-methyl-N-nitrosourea (MNU) was administered to a separate group of rasH2-Tg mice by single intraperitoneal injection (75 mg/kg) as a… CONTINUE READING