Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium.

@article{Alafuzoff2006InterlaboratoryCO,
  title={Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium.},
  author={Irina Alafuzoff and Maria Pikkarainen and Safa Al-Sarraj and Thomas Arzberger and Jeanne Bell and Istv{\'a}n B{\'o}di and Nenad Bogdanovi{\'c} and H Budka and Orso Bugiani and Isidro Ferrer and Ellen Gelp{\'i} and Giorgio Giaccone and Manuel Gr{\"a}ber and Jean Jacques Hauw and Wouter Kamphorst and Andrew King and Nicolas Videla Kopp and Penelope Korkolopoulou and Gabor G Kovacs and David Meyronet and Piero Parchi and Efstratios Patsouris and Matthias Preusser and Rivka Ravid and Wolfgang Roggendorf and Danielle Seilhean and Nathalie Streichenberger and Dietmar Rudolf Thal and Hans A. Kretzschmar},
  journal={Journal of neuropathology and experimental neurology},
  year={2006},
  volume={65 8},
  pages={
          740-57
        }
}
This interlaboratory study evaluated the reproducibility of the assessments of neuritic plaques and neurofibrillary tangles (NFTs)--the hallmark lesions of Alzheimer disease--and compared the staining between the BrainNet Europe centers. To reduce the topography-related inconsistencies in assessments, we used a 2-mm tissue microarray (TMA) technique. The TMA block included 42 core samples taken from 21 paraffin blocks. The assessments were done on Bielschowsky and Gallyas silver stains using an… CONTINUE READING

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