Interlaboratory Validation of the In Vitro Eye Irritation Tests for Cosmetic Ingredients. (6) Evaluation of MATREX((TM)).

@article{Ohuchi1999InterlaboratoryVO,
  title={Interlaboratory Validation of the In Vitro Eye Irritation Tests for Cosmetic Ingredients. (6) Evaluation of MATREX((TM)).},
  author={Jiro Ohuchi and Yasushi Kasai and Kazuhiko Sakamoto and Mio Ohnuma and Masahiro Kitamura and Yoshimasa Kawasaki and Hiroshi Kakishima and Hiroo Kuwahara and Yoshinori Imanishi and Hiroshi Tatsumi and Mayumi Kotani and Kaori Inoue and Hidenobu Okumura and Masaki Arashima and A Kurishita and Sachiko Kinoshita and Naoko Tani and Hajime Kojima and Takashi Nakamura and Ken-ichirou Suzuki and Takuya Ishibashi and Hirosi Hori and Hidekazu Takahashi and Tomo Nishikawa and Yasunori Kitano and Yasuo Ohno},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1999},
  volume={13 1},
  pages={153-62}
}
MATREX(TM) is a test system for evaluating eye irritation potential, using the living dermal model (LDM). The LDM consists of normal human dermal fibroblasts in a contracted collagen lattice, which eventually forms a three-dimensional structure. This system has several advantages. It can be applied to insoluble substances and does not require sterile conditions for operation. In the present study, MATREX was introduced as an alternative to the Draize eye irritation test (Draize test) for… CONTINUE READING

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