Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes.

  title={Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes.},
  author={Glenna J. Kramer and Akif Mohd and Sylva L. U. Schwager and G. Masuyer and K. Ravi Acharya and Edward D. Sturrock and B. Bachmann},
  journal={ACS medicinal chemistry letters},
  volume={5 4},
  • Glenna J. Kramer, Akif Mohd, +4 authors B. Bachmann
  • Published 2014
  • Biology, Medicine
  • ACS medicinal chemistry letters
  • The K-26 family of bacterial secondary metabolites are N-modified tripeptides terminated by an unusual phosphonate analog of tyrosine. These natural products, produced via three different actinomycetales, are potent inhibitors of human angiotensin-I converting enzyme (ACE). Herein we investigate the interkingdom pharmacology of the K-26 family by synthesizing these metabolites and assessing their potency as inhibitors of both the N-terminal and C-terminal domains of human ACE. In most cases… CONTINUE READING
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