Interkinetic nuclear migration is centrosome independent and ensures apical cell division to maintain tissue integrity.
@article{Strzyz2015InterkineticNM, title={Interkinetic nuclear migration is centrosome independent and ensures apical cell division to maintain tissue integrity.}, author={Paulina J Strzyz and Hyun O. Lee and Jaydeep Sidhaye and Isabell P Weber and Louis C. Leung and Caren Norden}, journal={Developmental cell}, year={2015}, volume={32 2}, pages={ 203-19 } }
81 Citations
Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development
- BiologyCurrent Biology
- 2020
The actin cytoskeleton governs apical mitosis and daughter cell dispersion in intestinal epithelia
- BiologybioRxiv
- 2017
Polarized rearrangements of the actin cytoskeleton govern the mitotic behavior of intestinal epithelial cells and lead to interspersion of cell lineages, which allows neighboring cells to insert between nascent daughters, intermingling cells of different lineages.
Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions.
- BiologyCell reports
- 2020
Mitotic spindle orientation in epithelial homeostasis and plasticity.
- BiologyJournal of biochemistry
- 2018
The mechanism by which planar spindle orientation is tightly regulated is described and the roles of mitotic spindle Orientation in epithelial development and disease are discussed.
Collective epithelial migration drives timely morphogenesis of the retinal neuroepithelium
- Biology
- 2016
It is shown that, surprisingly, active collective epithelial migration of cells at the rim of the cup is the most prominent player in RNE formation.
Tissue shape determines actin-dependent nuclear migration mechanisms in neuroepithelia
- BiologybioRxiv
- 2019
It is suggested that cytoskeleton adaptability to tissue shape ensures correct nuclear positioning and robust epithelial maturation across different geometries andDifferent mechanisms arise due to differences in actin arrangements during development, highlighting the importance of developmental context for the execution of intracellular processes.
Sun1 mediates interkinetic nuclear migration and Notch signaling in the neurogenesis of zebrafish.
- BiologyStem cells and development
- 2019
It is suggested that the Sun1-mediated nucleo-cytoskeletal interaction contributes to apical nuclear migration, and may thus affect exposure to Notch signal, thereby altering the composition of the progenitor pool, in the embryonic neurogenesis of zebrafish.
Heterogeneity, Cell Biology and Tissue Mechanics of Pseudostratified Epithelia: Coordination of Cell Divisions and Growth in Tightly Packed Tissues.
- BiologyInternational review of cell and molecular biology
- 2016
Pseudostratified epithelia – cell biology, diversity and roles in organ formation at a glance
- BiologyJournal of Cell Science
- 2017
The cell biology of PSEs is discussed, highlighting how differences in PSE architecture could influence cellular behaviour, especially IKNM and the links between apical mitosis and tissue integrity and maturation are summarized.
Nuclear migration events throughout development
- BiologyJournal of Cell Science
- 2016
How proteins and various mechanisms move nuclei during vertebrate development, including processes related to wound healing of fibroblasts, fertilization, developing myotubes and the developing central nervous system, are focused on.
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Interkinetic Nuclear Migration Is a Broadly Conserved Feature of Cell Division in Pseudostratified Epithelia
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The data support a novel model for neurogenesis, in which interkinetic nuclear migration differentially positions nuclei in neuroepithelial cells and therefore influences selection of progenitors for cell cycle exit based on apical–basal polarized signals.
Apical migration of nuclei during G2 is a prerequisite for all nuclear motion in zebrafish neuroepithelia
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A quantitative analysis of modes of nuclear migration during the cell cycle using a marker that enables the first unequivocal differentiation of all four phases in proliferating neuroepithelial cells in vivo suggests that IKNM involves an actomyosin-driven contraction of cytoplasm basal to the nucleus during G2, and that the stochastic nuclear movements observed in other phases arise passively due to apical migration in neighboring cells.
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The model for INM explains how the dynamics of neural progenitors harmonize their extensive proliferation with the epithelial architecture in the developing brain.
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