Interisland Evolution of Trimeresurus flavoviridis Venom Phospholipase A2 Isozymes

  title={Interisland Evolution of Trimeresurus flavoviridis Venom Phospholipase A2 Isozymes},
  author={Takahito Chijiwa and Yoko Yamaguchi and Tomohisa Ogawa and Masanobu Deshimaru and Ikuo Nobuhisa and Kinichi Nakashima and Naoko Oda-Ueda and Yasuyuki Fukumaki and Sh{\^o}saku Hattori and Motonori Ohno},
  journal={Journal of Molecular Evolution},
Abstract Trimeresurus flavoviridis snakes inhabit the southwestern islands of Japan. A phospholipase A2 (PLA2), named PL-Y, was isolated from Okinawa T. flavoviridis venom and its amino acid sequence was determined from both protein and cDNA. PL-Y was unable to induce edema. In contrast, PLA-B, a PLA2 from Tokunoshima T. flavoviridis venom, which is different at only three positions from PL-Y, is known to induce edema. A new PLA2, named PLA-B′, which is similar to PLA-B, was cloned from Amami… CONTINUE READING


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