Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence.

@article{Eap2002InterindividualVO,
  title={Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence.},
  author={Chin B. Eap and Thierry Buclin and Pierre Baumann},
  journal={Clinical pharmacokinetics},
  year={2002},
  volume={41 14},
  pages={1153-93}
}
Methadone is widely used for the treatment of opioid dependence. Although in most countries the drug is administered as a racemic mixture of (R)- and (S)- methadone, (R)-methadone accounts for most, if not all, of the opioid effects. Methadone can be detected in the blood 15-45 minutes after oral administration, with peak plasma concentration at 2.5-4 hours. Methadone has a mean bioavailability of around 75% (range 36-100%). Methadone is highly bound to plasma proteins, in particular to alpha(1… CONTINUE READING
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