Interindividual variability of once-daily ritonavir boosted saquinavir pharmacokinetics in Thai and UK patients.

@article{Autar2005InterindividualVO,
  title={Interindividual variability of once-daily ritonavir boosted saquinavir pharmacokinetics in Thai and UK patients.},
  author={Reshma Saskia Autar and Marta Boffito and Elly A. M. Hassink and Ferdinand W. N. M. Wit and Jintanat Ananworanich and Umaporn Siangphoe and Anton Louis Pozniak and David A. Cooper and Praphan Phanuphak and Joep M. A. Lange and Kiat Ruxrungtham and David M Burger},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={56 5},
  pages={908-13}
}
OBJECTIVES Differential exposure to saquinavir/ritonavir may lead to therapy failure. The objective was to identify factors that influence variability of saquinavir/ritonavir plasma concentrations. METHODS Saquinavir/ritonavir data, dosed as 1600/100 mg once daily, from three separate pharmacokinetic studies, in 45 patients from Thailand and the UK, were pooled. Pharmacokinetic parameters were based on non-compartmental analysis. Univariate analysis was performed with saquinavir as the… CONTINUE READING