Interindividual variability in inhibition and induction of cytochrome P450 enzymes.

  title={Interindividual variability in inhibition and induction of cytochrome P450 enzymes.},
  author={Jiunn Huei Lin and A. Y. Lu},
  journal={Annual review of pharmacology and toxicology},
Drug interactions have always been a major concern in medicine for clinicians and patients. Inhibition and induction of cytochrome P450 (CYP) enzymes are probably the most common causes for documented drug interactions. Today, many pharmaceutical companies are predicting potential interactions of new drug candidates. Can in vivo drug interactions be predicted accurately from in vitro metabolic studies? Should the prediction be qualitative or quantitative? Although some scientists believe that… CONTINUE READING

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